S/MARt DB - S/MARbinder

AC  SB000004
XX
DT  1.1.1999 00:00:00 (created); ili
DT  30.3.2004 13:54:00 (updated); ili2
XX
NA  lamin C
XX
OS  rat, Rattus norvegicus
OC  eukaryota; animalia; metazoa; chordata; vertebrata;
OC  tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae;
OC  murinae
XX
SF  belongs to type A lamins [5]; central alpha-helical rod
SF  domain flanked by a short nonhelical heat and a long
SF  nonhelical carboxy terminus [4] [5]; may self-assemble
SF  into long polymers in which the rod domains are dimerized
SF  to coiled-coil molecules [4]
XX
FF  observed in aggregates that bind MAR-DNA [2] [4]; does
FF  not bind MAR-DNA in Southwestern assay [2]; polymers of
FF  lamin A, B1 & C bind through single-stranded regions and
FF  minor groove contact [4]; no binding to DNA at 15 C
FF  [1]
XX
IN  SB000002; lamin A
IN  SB000003; lamin B1
XX
CP  liver [2]
CN  spermatogenic cells [3]
XX
BS  SM0000001; MOUSE$kappa-MAR [4]
MM  nitrocellulose filter binding;
SO  rl; rat
QA  6
BS  SM0000037; DROME$H1H3 [4]
MM  nitrocellulose filter binding;
SO  rl; rat
QA  6
BS  SM0000037; DROME$H1H3 [4]
MM  replacement by distamycin A;
SO  rl; rat
QA  6
BS  SM0000037; DROME$H1H3 [4]
MM  replacement by chromomycin;
SO  rl; rat
QA  6
BS  SM0000050; RAT$GDH-5MAR [4]
MM  nitrocellulose filter binding;
SO  rl; rat
QA  6
XX
DR  SwissProt: Q62741; Q62741
XX
RN  [1]
RX  MEDLINE; 91250423 PubMed; 2040622
RA  Hakes, D. J., Berezney, R.
RT  DNA binding properties of the nuclear matrix and individual
RT  nuclear matrix proteins. Evidence for salt-resistant DNA
RT  binding sites
RL  J. Biol. Chem. 266:11131-11140 (1991)
RN  [2]
RX  MEDLINE; 92405165 PubMed; 1525831
RA  Luderus, M. E. E., de Graaf, A., Mattia, E., den Blaauwen,
RA  J. L., Grande, M. A., de Jong, L., van Driel, R.
RT  Binding of matrix attachment regions to lamin B1
RL  Cell 70:949-959 (1992)
RN  [3]
RX  MEDLINE; 93280257 PubMed; 8505378
RA  Vester, B., Smith, A., Krohne, G., Benavente, R.
RT  Presence of a nuclear lamina in pachytene spermatocytes of
RT  the rat
RL  J. Cell Sci. 104:557-563 (1993)
RN  [4]
RX  MEDLINE; 94344140 PubMed; 8065361
RA  Luderus, M. E. E., den Blaauwen, J. L., de Smit, O. J. B.,
RA  Compton, D. A., van Driel, R.
RT  Binding of matrix attachment regions to lamin polymers
RT  involves single-stranded regions and the minor groove
RL  Mol. Cell. Biol. 14:6297-6305 (1994)
RN  [5]
RX  MEDLINE; 20114667 PubMed; 10651245
RA  Goldberg, M., Harel, A., Gruenbaum, Y.
RT  The nuclear lamina: molecular organization and interaction
RT  with chromatin
RL  Crit. Rev. Eukaryot. Gene Expr. 9:285-293 (1999)
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