S/MARt DB - S/MAR

AC  SM0000141
XX
DT  23.4.1999 14:14:19 (created); ili
DT  13.6.2001 15:38:00 (updated); ili
XX
NA  HS$GLOBE-5MAR1
XX
SY  epsilon SAR, 
XX
OS  human, Homo sapiens
OC  eukaryota; animalia; metazoa; chordata; vertebrata;
OC  tetrapoda; mammalia; eutheria; primates
XX
SZ  ca. 2000 bp
XX
LO  11p15.5
DE  G000261; Agamma-globin
DP  Direction: 5'; Pos 1: transcriptional start
DN  Internal: n; Gene position numeral: 3
DE  G000253; epsilon-globin
DP  Direction: 5'; Pos 1: transcriptional start
DN  Internal: n; Gene position numeral: 1
DC  refers to the proximal S/MAR 5' to the epsilon-globin gene
DC  [1]
DE  G001095; Ggamma-globin
DP  Direction: 5'; Pos 1: transcriptional start
DN  Internal: n; Gene position numeral: 2

G000253;
epsilon-globin
G001095;
Ggamma-globin
G000261;
Agamma-globin

XX
FF  caution: named beta-globin SAR in [3]; found not to be
FF  attached when using the high salt method for matrix
FF  preparation [2]; low affinity to tobacco scaffolds
FF  [3]
XX
CP  K562 cells [1]
XX
EV  in vivo selection/LIS [1]
XX
RN  [1]
RX  MEDLINE; 89091073 PubMed; 3208739
RA  Jarman, A. P., Higgs, D.R.
RT  Nuclear scaffold attachment sites in the human globin gene
RT  complexes
RL  EMBO J. 7:3337-3344 (1988)
RN  [2]
RX  MEDLINE; 93062867 PubMed; 1435759
RA  Bartjeliotou, A. J., Dimitriadis, G. J.
RT  The association of the human epsilon-globin gene with the
RT  nucleart matrix: a reconsideration
RL  Mol. Cell. Biochem. 115:105-115 (1992)
RN  [3]
RX  MEDLINE; 92361263 PubMed; 1498604
RA  Breyne, P., van Montagu, M., Depicker, A., Gheysen, G.
RT  Characterization of a plant scaffold attachment region in a
RT  DNA fragment that normalizes transgene expression in tobacco
RL  Plant Cell 4:463-471 (1992)
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