S/MARt DB - S/MAR

AC  SM0000434
XX
DT  25.6.2002 11:25:00 (created); ili
DT  25.6.2002 14:16:00 (updated); ili
XX
NA  HS$MLLT3-3MAR2
XX
SY  AF9 SAR2, 
XX
OS  human, Homo sapiens
OC  eukaryota; animalia; metazoa; chordata; vertebrata;
OC  tetrapoda; mammalia; eutheria; primates
XX
LO  9p22
DE  G004505; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
DP  Direction: 3'; Pos 1: transcriptional start
DN  Internal: y; Gene position numeral: 0
DC  comprises parts of introns 5 to 7 [1]
XX
SF  multiple A/T tracts [1]
XX
FF  surrounded by breakpoint cluster regions 1 and 2 [1]
XX
EV  in vivo selection/LIS [1]
XX
RN  [1]
RX  MEDLINE; 20320697 PubMed; 10861294
RA  Strissel, P. L., Strick, R., Tomek, R. J., Roe, B. A.,
RA  Rowley, J. D., Zeleznik-Le, N. J.
RT  DNA structural properties of AF9 are similar to MLL and
RT  could act as recombination hot spots resulting in MLL/AF9
RT  translocations and leukemogenesis
RL  Hum. Mol. Genet. 9:1671-1679 (2000)
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