S/MARt DB - S/MAR

AC  SM0000534
XX
DT  2.8.2004 11:18:00 (created); ili2
DT  12.10.2004 11:12:00 (updated); ili2
XX
NA  HS$IFNB1-5MAR
XX
OS  human, Homo sapiens
OC  eukaryota; animalia; metazoa; chordata; vertebrata;
OC  tetrapoda; mammalia; eutheria; primates
XX
LO  9p22
DE  G000308; interferon-beta 1
DP  Direction: 5'; Pos 1: ATG
DN  Internal: n; Gene position numeral: 1

G000308;
interferon-beta 1

XX
SF  comprises at least IFNB1 fragments I, E, H SF  SM0000002, SM0000009>, being fragment I the most distal and
SF  fragment H the proximal one [1]
XX
FF  not every copy of the S/MAR is anchored to the nuclear
FF  matrix when present in multiple copies [2]; transfected
FF  mouse fibroblast cell lines containing different copy
FF  numbers show a non-linear relationship between the IFN beta
FF  expression and the number of insertions [2]; expression
FF  level correlates well with the anchoring pattern in cell
FF  lines containing multiple copies [2]; please look up
FF  entries  for more
FF  information
XX
EV  flourescence in situ hybridization (FISH) [2]
EC  at low copy number more than 90% were found attached [2]
XX
RN  [1]
RX  MEDLINE; 89000669 PubMed; 2844236
RA  Bode, J., Maass, K.
RT  Chromatin domain surrounding the human interferon-beta gene
RT  as defined by scaffold-attached regions
RL  Biochemistry 27:4706-4711 (1988)
RN  [2]
RX  MEDLINE;  PubMed; 14996931
RA  Heng, H. H. Q., Goetze, S., Ye, C. J., LIU G., Stevens, J.
RA  B., Bremer, S. W., Wykes, S. M., Bode, J., Krawetz, S. A.
RT  Chromatin loops are selectively anchored using
RT  scaffold/matrix-attachment regions
RL  J. Cell Sci. 117:999-1008 (2004)
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