S/MARt DB - S/MAR

AC  SM0000535
XX
DT  2.8.2004 16:32:00 (created); ili2
DT  14.12.2004 14:25:00 (updated); ili2
XX
NA  HS$IFNB1-3MAR
XX
OS  human, Homo sapiens
OC  eukaryota; animalia; metazoa; chordata; vertebrata;
OC  tetrapoda; mammalia; eutheria; primates
XX
LO  9p22
DE  G000308; interferon-beta 1
DP  Direction: 3'; Pos 1: ATG
DN  Internal: n; Gene position numeral: -1

G000308;
interferon-beta 1

XX
SF  comprises at IFNB1 fragments D and G SF  SM0000005>, being fragment D the proximal one [1]
XX
FF  please look up entries  for more
FF  information; can enhance retroviral vector expression in
FF  quiescent T cells [2]; improves longterm retroviral
FF  vector expresion [3]; does not confer
FF  position-independent expression to a transgene [2]; has
FF  an inhibitory effect of methylation on retroviral
FF  expression in stably transfected cells [3]; allevates
FF  to some extent methylation-mediated transcriptional
FF  repression [3]
XX
RN  [1]
RX  MEDLINE; 89000669 PubMed; 2844236
RA  Bode, J., Maass, K.
RT  Chromatin domain surrounding the human interferon-beta gene
RT  as defined by scaffold-attached regions
RL  Biochemistry 27:4706-4711 (1988)
RN  [2]
RX  MEDLINE;  PubMed; 9557654
RA  Agarwal, M., Austin, T. W., Morel, F., Chen, J., Boehnlein,
RA  E., Plavec, I.
RT  Scaffold attachment region-mediated enhancement of
RT  retroviral vector expression in primary T cells
RL  J. Virol. 72:3720-3728 (1998)
RN  [3]
RX  MEDLINE;  PubMed; 10684282
RA  Dang, Q., Auten, J., Plavec, I.
RT  Human beta interferon scaffold attachment region inhibits
RT  de novo methylation and confers long-term, copy
RT  number-dependent expression to a retroviral vector
RL  J. Virol. 74:2671-2678 (2000)
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